Ivermectin lotion (sklice) for head lice.

There have been no reports of serious adverse reactions with the use of topical ivermectin in a limited number of patients (i.e., fewer than 400).1,2 Ivermectin 0.5% lotion does not have the neurotoxicity concerns of lindane or the flammability concerns of malathion (Ovide).2,3 The safety of the lotion has not been established in patients younger than six months, and use in this age group is not recommended because of the potential risk of increased systemic absorption and ivermectin toxicity.1 Topical ivermectin is classified as a U.S. Food and Drug Administration pregnancy category C drug, and its excretion in breast milk has not been studied.1